Polysaccharide Biosynthesis

Polysaccharide Biosynthesis

Polysaccharide synthesis is discussed from the point of view of the sources of biological information that determine the structures and control the rates of synthesis of complex polysaccharides. It is concluded that three types of information contribute in important and different ways, namely enzyme specificity, primer substances, and the structure of the cytoplasmic membrane. Each of these fac...

Genetic Loci for Coaggregation Receptor Polysaccharide Biosynthesis

Biosynthesis of the Polysaccharide of Micrococcus Cell Walls lysodeikticus I. CHARACTERIZATION OF AN IN VITRO SYSTEM FOR POLYSACCHARIDE BIOSYNTHESIS*

The particulate enzyme fraction obtained from Micrococcus Zysodeikficus catalyzed the incorporation of D-[r4C]glucose from uridine diphospho-n-[r4C]glucose into a polymer which resembled the n-glucoseand N-acetyl-n-mannosaminuronic acid-containing polysaccharide of the cell walls of this organism. In vifro biosynthesis of the polysaccharide depended upon the presence of the uridine diphospho-Na...

Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme

Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. The principal CPS of the human pathogen and Tier 1 select agent Burkholderia pseudomallei consists of a linear repeat of --3)--2-O-acetyl-6-deoxy-β-d-manno-heptopyranose-(1-. This CPS is critical to the virulence of this emerging pathogen and represents a key target for the development of n...

The biosynthesis of capsular polysaccharide in Aerobacter aerogenes.